Coronary, aortic and carotid artery inflammation by 18F-fluorodeoxyglucose positron emission tomography in acute and chronic coronary artery disease

Abstract Funding Acknowledgements Type of funding sources: None. Background 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) can detect arterial inflammation in individuals with atherosclerosis, but the associations among different vascular territories for 18F-FDG uptake are not known. Purpose We explored any possible correlation between quantified by PET aorta, carotid arteries, and coronary arteries patients presenting acute syndrome (ACS), or chronic artery disease (CAD). Methods Prospectively, we performed hybrid computed angiography 43 (26 ACS 17 CAD) at 6.6 ± 5.7 days following invasive angiography. was 90 minutes after injection 302.2 28.4 MBq 18F-FDG. Arterial measured thoracic expressed as target-to-background ratio (TBR; maximal standardized value normalized to blood pool mean value) whole artery, most diseased segment (MDS). Results Mean age 64.9 9.1 years, 90.7% males. The higher aorta than (median TBR 2.23, interquartile range [0.36] vs. 1.88 [0.42], p < 0.001); whereas lower (1.13 [0.23], 0.001 both). Similarly, aortic MDS (2.75 [0.62] 2.25 [0.63], lowest (1.40 [0.33], These findings were consistent both CAD patients. correlated (r = 0.58, 0.002), 0.21, 0.3). There no either cohort (r=-0.16, 0.2, r 0.01, 0.9, respectively), 0.06, 0.7, r=-0.01, those (r=-0.4, 0.1, r=-0.09, respectively). Conclusions In CAD, large had arteries. intensity did correlate that indicating activity differs